Path ID: DB00555_MESH_D004828_1

db00555-mesh-d004828-1

Concepts

Identifier Name Type
MESH:C047781 lamotrigine Drug
InterPro:IPR001696 Voltage gated sodium channel, alpha subunit GeneFamily
GO:0061530 aspartate secretion, neurotransmission BiologicalProcess
GO:0061535 glutamate secretion, neurotransmission BiologicalProcess
HP:0032843 Focal-onset epileptic spasm PhenotypicFeature
MESH:D004828 Epilepsies, Partial Disease

Relationships

NOTE: predicates are annotated in Biolink Model (v1.3.0)

Subject Predicate Object
Lamotrigine NEGATIVELY REGULATES Voltage Gated Sodium Channel, Alpha Subunit
Voltage Gated Sodium Channel, Alpha Subunit POSITIVELY REGULATES Aspartate Secretion, Neurotransmission
Voltage Gated Sodium Channel, Alpha Subunit POSITIVELY REGULATES Glutamate Secretion, Neurotransmission
Aspartate Secretion, Neurotransmission POSITIVELY CORRELATED WITH Focal-Onset Epileptic Spasm
Glutamate Secretion, Neurotransmission POSITIVELY CORRELATED WITH Focal-Onset Epileptic Spasm
Focal-Onset Epileptic Spasm POSITIVELY CORRELATED WITH Epilepsies, Partial

Comment: This drug may also affect GABA-mediated synaptic transmission as listed by DrugBank (https://go.drugbank.com/drugs/DB00555#BE0000013). However, this is contentious and if the drug does modulate GABA it’s not known whether it is as agonist or antagonist due to conflicting data (at best it would be a weak modulation seen in animal models only). Note that the drug could be contraindicated for treatment of seizures as it can exacerbate them, specially the myoclonic type (https://pubmed.ncbi.nlm.nih.gov/9596203/). Finally, this disease is denoted as Simple partial seizure in the original file but known as Epilepsies, Partial in MESH.

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