Path ID: DB00549_MESH_D001249_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:C062735 | Zafirlukast | Drug |
| UniProt:Q9Y271 | Cysteinyl leukotriene receptor 1 | Protein |
| GO:0001631 | Cysteinyl leukotriene receptor activity | MolecularActivity |
| GO:0006939 | Smooth muscle contraction | BiologicalProcess |
| UBERON:0002185 | Bronchus | GrossAnatomicalStructure |
| GO:0006954 | Inflammatory response | BiologicalProcess |
| MESH:D001249 | Asthma | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Zafirlukast | DECREASES ACTIVITY OF | Cysteinyl Leukotriene Receptor 1 |
| Cysteinyl Leukotriene Receptor 1 | PARTICIPATES IN | Cysteinyl Leukotriene Receptor Activity |
| Cysteinyl Leukotriene Receptor Activity | POSITIVELY REGULATES | Smooth Muscle Contraction |
| Smooth Muscle Contraction | LOCATED IN | Bronchus |
| Bronchus | LOCATION OF | Asthma |
| Cysteinyl Leukotriene Receptor Activity | PARTICIPATES IN | Inflammatory Response |
| Inflammatory Response | CAUSES | Asthma |
Comment: Zafirlukast is an oral leukotriene receptor antagonist (LTRA) for the maintenance treatment of asthma, often used in conjunction with an inhaled steroid and/or long-acting bronchodilator.
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