Path ID: DB00547_MESH_D011538_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:D003899 | Desoximetasone | Drug |
| UniProt:P04150 | Glucocorticoid receptor | Protein |
| UniProt:P04083 | Annexin A1 | Protein |
| reactome:R-HSA-2162123 | Prostaglandin Synthesis | Pathway |
| GO:0006954 | Inflammatory response | BiologicalProcess |
| HP:0000989 | Skin itching | PhenotypicFeature |
| MESH:D011538 | Pruritus ani | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Desoximetasone | INCREASES ACTIVITY OF | Glucocorticoid Receptor |
| Glucocorticoid Receptor | INCREASES ABUNDANCE OF | Annexin A1 |
| Annexin A1 | NEGATIVELY REGULATES | Prostaglandin Synthesis |
| Prostaglandin Synthesis | POSITIVELY REGULATES | Inflammatory Response |
| Inflammatory Response | CONTRIBUTES TO | Skin Itching |
| Skin Itching | MANIFESTATION OF | Pruritus Ani |
Reference: