Path ID: DB00544_MESH_D003110_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:D005472 | Fluorouracil | Drug |
| UniProt:P04818 | Thymidylate synthase | Protein |
| MESH:D004247 | DNA | ChemicalSubstance |
| MESH:D012313 | RNA | ChemicalSubstance |
| GO:0071897 | DNA biosynthetic process | BiologicalProcess |
| GO:0032774 | RNA biosynthetic process | BiologicalProcess |
| MESH:D003110 | Malignant tumor of colon | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Fluorouracil | DECREASES ACTIVITY OF | Thymidylate Synthase |
| Thymidylate Synthase | POSITIVELY REGULATES | Dna Biosynthetic Process |
| Fluorouracil | DISRUPTS | Dna |
| Dna | PARTICIPATES IN | Dna Biosynthetic Process |
| Dna Biosynthetic Process | OCCURS IN | Malignant Tumor Of Colon |
| Fluorouracil | DISRUPTS | Rna |
| Rna | PARTICIPATES IN | Rna Biosynthetic Process |
| Rna Biosynthetic Process | OCCURS IN | Malignant Tumor Of Colon |
Reference: