Path ID: DB00540_MESH_D003866_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:D009661 | nortriptyline | Drug |
| UniProt:P23975 | Sodium-dependent noradrenaline transporter | Protein |
| UniProt:P31645 | Sodium-dependent serotonin transporter | Protein |
| GO:0051610 | serotonin uptake | BiologicalProcess |
| GO:0051620 | norepinephrine uptake | BiologicalProcess |
| MESH:D003866 | Depressive disorder | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Nortriptyline | NEGATIVELY REGULATES | Sodium-Dependent Noradrenaline Transporter |
| Nortriptyline | NEGATIVELY REGULATES | Sodium-Dependent Serotonin Transporter |
| Sodium-Dependent Noradrenaline Transporter | POSITIVELY REGULATES | Norepinephrine Uptake |
| Sodium-Dependent Serotonin Transporter | POSITIVELY REGULATES | Serotonin Uptake |
| Serotonin Uptake | POSITIVELY CORRELATED WITH | Depressive Disorder |
| Norepinephrine Uptake | POSITIVELY CORRELATED WITH | Depressive Disorder |
Reference: