Path ID: DB00537_MESH_D014435_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:D002939 | ciprofloxacin | Drug |
| UniProt:A0A717UR96 | DNA gyrase subunit A | Protein |
| UniProt:A0A715KJC7 | DNA topoisomerase 4 subunit A | Protein |
| GO:0006260 | DNA replication | BiologicalProcess |
| taxonomy:90370 | Salmonella enterica subsp. enterica serovar Typhi | OrganismTaxon |
| MESH:D014435 | Typhoid Fever | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Ciprofloxacin | DECREASES ACTIVITY OF | Dna Gyrase Subunit A |
| Ciprofloxacin | DECREASES ACTIVITY OF | Dna Topoisomerase 4 Subunit A |
| Dna Gyrase Subunit A | POSITIVELY REGULATES | Dna Replication |
| Dna Topoisomerase 4 Subunit A | POSITIVELY REGULATES | Dna Replication |
| Dna Replication | OCCURS IN | Salmonella Enterica Subsp. Enterica Serovar Typhi |
| Salmonella Enterica Subsp. Enterica Serovar Typhi | CAUSES | Typhoid Fever |
Comment: Ciprofloxacin is a second generation fluoroquinolone that is used to treat a wide variety of bacterial susceptible infections.
Reference: