Path ID: DB00537_MESH_D011018_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:D002939 | ciprofloxacin | Drug |
| UniProt:P72524 | DNA gyrase subunit A | Protein |
| UniProt:P72525 | DNA topoisomerase 4 subunit A | Protein |
| GO:0006260 | DNA replication | BiologicalProcess |
| taxonomy:1313 | Streptococcus pneumoniae | OrganismTaxon |
| MESH:D011018 | Pneumonia, Pneumococcal | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Ciprofloxacin | DECREASES ACTIVITY OF | Dna Gyrase Subunit A |
| Ciprofloxacin | DECREASES ACTIVITY OF | Dna Topoisomerase 4 Subunit A |
| Dna Gyrase Subunit A | POSITIVELY REGULATES | Dna Replication |
| Dna Topoisomerase 4 Subunit A | POSITIVELY REGULATES | Dna Replication |
| Dna Replication | OCCURS IN | Streptococcus Pneumoniae |
| Streptococcus Pneumoniae | CAUSES | Pneumonia, Pneumococcal |
Comment: Ciprofloxacin is a second generation fluoroquinolone that is used to treat a wide variety of bacterial susceptible infections.
Reference: