Path ID: DB00536_MESH_D015624_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:D019791 | guanidine | Drug |
| Pfam:PF03520 | KCNQ voltage-gated potassium channel | GeneFamily |
| GO:0007274 | neuromuscular synaptic transmission | BiologicalProcess |
| HP:0003690 | Limb muscle weakness | PhenotypicFeature |
| MESH:D015624 | Eaton-Lambert syndrome | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Guanidine | DISRUPTS | Kcnq Voltage-Gated Potassium Channel |
| Kcnq Voltage-Gated Potassium Channel | POSITIVELY REGULATES | Neuromuscular Synaptic Transmission |
| Neuromuscular Synaptic Transmission | AFFECTS RISK FOR | Limb Muscle Weakness |
| Limb Muscle Weakness | MANIFESTATION OF | Eaton-Lambert Syndrome |
Comment: Guanidine is known to causes many side effects; therefore it’s not recommended.
Reference: