Path ID: DB00533_MESH_D004412_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:C116926 | Rofecoxib | Drug |
| UniProt:P35354 | Prostaglandin G/H synthase 2 | Protein |
| reactome:R-HSA-2162123 | Synthesis of Prostaglandins (PG) and Thromboxanes (TX) | BiologicalProcess |
| MESH:D011453 | Prostaglandins | ChemicalSubstance |
| GO:0006954 | Inflammatory response | BiologicalProcess |
| HP:0012531 | Pain | PhenotypicFeature |
| MESH:D004412 | Dysmenorrhea | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Rofecoxib | DECREASES ACTIVITY OF | Prostaglandin G/H Synthase 2 |
| Prostaglandin G/H Synthase 2 | PARTICIPATES IN | Synthesis Of Prostaglandins (Pg) And Thromboxanes (Tx) |
| Synthesis Of Prostaglandins (Pg) And Thromboxanes (Tx) | INCREASES ABUNDANCE OF | Prostaglandins |
| Prostaglandins | POSITIVELY REGULATES | Inflammatory Response |
| Inflammatory Response | POSITIVELY CORRELATED WITH | Pain |
| Pain | POSITIVELY CORRELATED WITH | Dysmenorrhea |
Reference: