Path ID: DB00521_MESH_D005902_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:D002354 | carteolol | Drug |
| UniProt:P08588 | Beta-1 adrenergic receptor | Protein |
| UniProt:P07550 | Beta-2 adrenergic receptor | Protein |
| reactome:R-HSA-418555 | G alpha (s) signalling events | Pathway |
| CHEBI:17489 | 3,5-cyclic AMP | ChemicalSubstance |
| UBERON:0001796 | aqueous humor of eyeball | GrossAnatomicalStructure |
| HP:0007906 | Ocular Hypertension | PhenotypicFeature |
| MESH:D005902 | Open-angle glaucoma | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Carteolol | DECREASES ACTIVITY OF | Beta-2 Adrenergic Receptor |
| Carteolol | DECREASES ACTIVITY OF | Beta-1 Adrenergic Receptor |
| Beta-2 Adrenergic Receptor | PARTICIPATES IN | G Alpha (S) Signalling Events |
| Beta-1 Adrenergic Receptor | PARTICIPATES IN | G Alpha (S) Signalling Events |
| G Alpha (S) Signalling Events | INCREASES ABUNDANCE OF | 3,5-Cyclic Amp |
| 3,5-Cyclic Amp | POSITIVELY CORRELATED WITH | Aqueous Humor Of Eyeball |
| Aqueous Humor Of Eyeball | POSITIVELY CORRELATED WITH | Ocular Hypertension |
| Ocular Hypertension | POSITIVELY CORRELATED WITH | Open-Angle Glaucoma |
Reference: