Path ID: DB00514_MESH_D020773_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:D003915 | dextromethorphan | Drug |
| DB:DB14682 | Dextrorphan | ChemicalSubstance |
| UniProt:P35367 | Histamine H1 receptor | Protein |
| GO:0004969 | histamine receptor activity | MolecularActivity |
| GO:0006954 | inflammatory response | BiologicalProcess |
| HP:0012531 | Pain | PhenotypicFeature |
| MESH:D020773 | Headache disorder | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Dextromethorphan | HAS METABOLITE | Dextrorphan |
| Dextrorphan | DECREASES ACTIVITY OF | Histamine H1 Receptor |
| Histamine H1 Receptor | POSITIVELY REGULATES | Histamine Receptor Activity |
| Histamine Receptor Activity | PARTICIPATES IN | Inflammatory Response |
| Inflammatory Response | POSITIVELY CORRELATED WITH | Pain |
| Pain | MANIFESTATION OF | Headache Disorder |
Comment: Dextromethorphan’s action on histamine receptors has been observed in rat tissues.
Reference: