Path ID: DB00514_MESH_D003371_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:D003915 | dextromethorphan | Drug |
| DB:DB14682 | Dextrorphan | ChemicalSubstance |
| UniProt:Q99720 | Sigma non-opioid intracellular receptor 1 | Protein |
| UniProt:P32297 | Neuronal acetylcholine receptor subunit alpha-3 | Protein |
| GO:0006939 | smooth muscle contraction | BiologicalProcess |
| GO:0060004 | reflex | BiologicalProcess |
| MESH:D003371 | Cough | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Dextromethorphan | HAS METABOLITE | Dextrorphan |
| Dextrorphan | INCREASES ACTIVITY OF | Sigma Non-Opioid Intracellular Receptor 1 |
| Dextrorphan | DECREASES ACTIVITY OF | Neuronal Acetylcholine Receptor Subunit Alpha-3 |
| Neuronal Acetylcholine Receptor Subunit Alpha-3 | REGULATES | Smooth Muscle Contraction |
| Smooth Muscle Contraction | CORRELATED WITH | Cough |
| Sigma Non-Opioid Intracellular Receptor 1 | NEGATIVELY REGULATES | Reflex |
| Reflex | POSITIVELY CORRELATED WITH | Cough |
Comment: Dextromethorphan acts centrally in the cough center in the medulla to suppress cough (https://pubmed.ncbi.nlm.nih.gov/18294576/). The drug is indicated in combination with guaifenesin as an over the counter product to relieve a cough.
Reference: