Path ID: DB00512_MESH_D004761_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:D014640 | vancomycin | Drug |
| CHEBI:16576 | D-alanyl-D-alanine | ChemicalSubstance |
| GO:0009275 | Gram-positive-bacterium-type cell wall | CellularComponent |
| GO:0018104 | peptidoglycan-protein cross-linking | BiologicalProcess |
| GO:0032774 | RNA biosynthetic process | BiologicalProcess |
| MESH:D010539 | Permeability | BiologicalProcess |
| taxonomy:1496 | Clostridioides difficile | OrganismTaxon |
| MESH:D004761 | Pseudomembranous enterocolitis | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Vancomycin | DISRUPTS | D-Alanyl-D-Alanine |
| Vancomycin | NEGATIVELY REGULATES | Peptidoglycan-Protein Cross-Linking |
| Peptidoglycan-Protein Cross-Linking | IN TAXON | Clostridioides Difficile |
| Vancomycin | NEGATIVELY REGULATES | Rna Biosynthetic Process |
| Rna Biosynthetic Process | IN TAXON | Clostridioides Difficile |
| Vancomycin | DISRUPTS | Permeability |
| Permeability | IN TAXON | Clostridioides Difficile |
| D-Alanyl-D-Alanine | LOCATED IN | Gram-Positive-Bacterium-Type Cell Wall |
| Gram-Positive-Bacterium-Type Cell Wall | IN TAXON | Clostridioides Difficile |
| Clostridioides Difficile | CAUSES | Pseudomembranous Enterocolitis |
Comment: Vancomycin is not active against Gram-negative bacteria (https://en.wikipedia.org/wiki/Vancomycin#Mechanism_of_action). MESH:D004761 is denoted as Enterocolitis, Pseudomembranous in the MESH website (https://meshb.nlm.nih.gov/record/ui?ui=D004761).
Reference: