Path ID: DB00509_MESH_D006949_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:D003918 | dextrothyroxine | Drug |
| UniProt:P10827 | Thyroid hormone receptor alpha | Protein |
| UniProt:P10828 | Thyroid hormone receptor beta | Protein |
| GO:0006707 | cholesterol catabolic process | BiologicalProcess |
| UniProt:P01130 | Low-density lipoprotein receptor | Protein |
| GO:0043691 | reverse cholesterol transport | BiologicalProcess |
| GO:0034381 | plasma lipoprotein particle clearance | BiologicalProcess |
| MESH:D006949 | Hyperlipidemias | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Dextrothyroxine | INCREASES ACTIVITY OF | Thyroid Hormone Receptor Alpha |
| Dextrothyroxine | INCREASES ACTIVITY OF | Thyroid Hormone Receptor Beta |
| Thyroid Hormone Receptor Alpha | POSITIVELY CORRELATED WITH | Cholesterol Catabolic Process |
| Thyroid Hormone Receptor Beta | INCREASES ACTIVITY OF | Low-Density Lipoprotein Receptor |
| Low-Density Lipoprotein Receptor | POSITIVELY CORRELATED WITH | Reverse Cholesterol Transport |
| Low-Density Lipoprotein Receptor | POSITIVELY CORRELATED WITH | Plasma Lipoprotein Particle Clearance |
| Cholesterol Catabolic Process | NEGATIVELY CORRELATED WITH | Hyperlipidemias |
| Reverse Cholesterol Transport | NEGATIVELY CORRELATED WITH | Hyperlipidemias |
| Plasma Lipoprotein Particle Clearance | NEGATIVELY CORRELATED WITH | Hyperlipidemias |
Reference: