Path ID: DB00502_MESH_D012559_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:D006220 | haloperidol | Drug |
| UniProt:P14416 | D(2) dopamine receptor | Protein |
| GO:0061527 | dopamine secretion, neurotransmission | BiologicalProcess |
| HP:0000709 | Psychosis | PhenotypicFeature |
| MESH:D012559 | Schizophrenia | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Haloperidol | NEGATIVELY REGULATES | D(2) Dopamine Receptor |
| D(2) Dopamine Receptor | POSITIVELY CORRELATED WITH | Dopamine Secretion, Neurotransmission |
| Dopamine Secretion, Neurotransmission | AFFECTS RISK FOR | Psychosis |
| Psychosis | MANIFESTATION OF | Schizophrenia |
Comment: Schizophrenia is theorized to be caused by a hyperdopaminergic state within the limbic system of the brain. So by inhibiting the binding of dopamine to its receptor, this drug may improve psychotic symptoms.
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