Path ID: DB00501_MESH_D034721_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:D002927 | Cimetidine | Drug |
| UniProt:P25021 | Histamine H2 receptor | Protein |
| GO:0004969 | histamine receptor activity | MolecularActivity |
| GO:0002553 | histamine secretion by mast cell | BiologicalProcess |
| HP:0001025 | Urticaria | PhenotypicFeature |
| HP:0012531 | Pain | PhenotypicFeature |
| MESH:D034721 | Mastocytosis, Systemic | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Cimetidine | DECREASES ACTIVITY OF | Histamine H2 Receptor |
| Histamine H2 Receptor | POSITIVELY REGULATES | Histamine Receptor Activity |
| Histamine Receptor Activity | POSITIVELY CORRELATED WITH | Histamine Secretion By Mast Cell |
| Histamine Secretion By Mast Cell | POSITIVELY REGULATES | Urticaria |
| Histamine Secretion By Mast Cell | POSITIVELY REGULATES | Pain |
| Urticaria | MANIFESTATION OF | Mastocytosis, Systemic |
| Pain | MANIFESTATION OF | Mastocytosis, Systemic |
Reference: