Path ID: DB00494_MESH_D010300_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:C071192 | entacapone | Drug |
| UniProt:P21964 | Catechol O-methyltransferase | Protein |
| GO:0102084 | L-dopa O-methyltransferase activity | MolecularActivity |
| CHEBI:15765 | L-dopa | ChemicalSubstance |
| GO:0001963 | synaptic transmission, dopaminergic | BiologicalProcess |
| MESH:D010300 | Parkinson’s disease | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Entacapone | NEGATIVELY REGULATES | Catechol O-Methyltransferase |
| Catechol O-Methyltransferase | POSITIVELY REGULATES | L-Dopa O-Methyltransferase Activity |
| L-Dopa O-Methyltransferase Activity | DECREASES ABUNDANCE OF | L-Dopa |
| L-Dopa | POSITIVELY CORRELATED WITH | Synaptic Transmission, Dopaminergic |
| Synaptic Transmission, Dopaminergic | NEGATIVELY CORRELATED WITH | Parkinson’S Disease |
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