Path ID: DB00489_MESH_D001281_1

db00489-mesh-d001281-1

Concepts

Identifier Name Type
MESH:D013015 Sotalol Drug
UniProt:P08588 Beta-1 adrenergic receptor Protein
UniProt:P07550 Beta-2 adrenergic receptor Protein
UniProt:Q12809 Potassium voltage-gated channel subfamily H member 2 Protein
GO:0005245 voltage-gated calcium channel activity MolecularActivity
GO:0005249 voltage-gated potassium channel activity MolecularActivity
GO:0060047 voltage-gated calcium channel activity BiologicalProcess
HP:0031860 Abnormal heart rate variability PhenotypicFeature
MESH:D001281 Atrial Fibrillation Disease

Relationships

NOTE: predicates are annotated in Biolink Model (v1.3.0)

Subject Predicate Object
Sotalol DECREASES ACTIVITY OF Beta-1 Adrenergic Receptor
Sotalol DECREASES ACTIVITY OF Beta-2 Adrenergic Receptor
Sotalol DECREASES ACTIVITY OF Potassium Voltage-Gated Channel Subfamily H Member 2
Beta-1 Adrenergic Receptor POSITIVELY REGULATES Voltage-Gated Calcium Channel Activity
Beta-2 Adrenergic Receptor POSITIVELY REGULATES Voltage-Gated Calcium Channel Activity
Potassium Voltage-Gated Channel Subfamily H Member 2 POSITIVELY REGULATES Voltage-Gated Potassium Channel Activity
Voltage-Gated Calcium Channel Activity POSITIVELY CORRELATED WITH Voltage-Gated Calcium Channel Activity
Voltage-Gated Potassium Channel Activity POSITIVELY CORRELATED WITH Voltage-Gated Calcium Channel Activity
Voltage-Gated Calcium Channel Activity POSITIVELY CORRELATED WITH Abnormal Heart Rate Variability
Abnormal Heart Rate Variability CONTRIBUTES TO Atrial Fibrillation

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