Path ID: DB00480_MESH_D009101_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:C467567 | Lenalidomide | Drug |
| GO:0001525 | Angiogenesis | BiologicalProcess |
| UniProt:Q96SW2 | Protein cereblon | Protein |
| UniProt:Q13422 | DNA-binding protein Ikaros | Protein |
| UniProt:Q9UKT9 | Zinc finger protein Aiolos | Protein |
| GO:0042098 | T cell proliferation | BiologicalProcess |
| GO:0030101 | Natural killer cell activation | BiologicalProcess |
| GO:0006915 | Apoptotic process | BiologicalProcess |
| GO:0071349 | Cellular response to interleukin-12 | BiologicalProcess |
| UniProt:P01375 | Tumor necrosis factor | Protein |
| GO:0071347 | Cellular response to interleukin-1 | BiologicalProcess |
| GO:0071354 | Cellular response to interleukin-6 | BiologicalProcess |
| MESH:D009101 | Multiple myeloma | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Lenalidomide | NEGATIVELY REGULATES | Angiogenesis |
| Angiogenesis | POSITIVELY CORRELATED WITH | Multiple Myeloma |
| Lenalidomide | MOLECULARLY INTERACTS WITH | Protein Cereblon |
| Protein Cereblon | INCREASES DEGRADATION OF | Dna-Binding Protein Ikaros |
| Protein Cereblon | INCREASES DEGRADATION OF | Zinc Finger Protein Aiolos |
| Dna-Binding Protein Ikaros | POSITIVELY CORRELATED WITH | Multiple Myeloma |
| Zinc Finger Protein Aiolos | POSITIVELY CORRELATED WITH | Multiple Myeloma |
| Lenalidomide | POSITIVELY REGULATES | T Cell Proliferation |
| T Cell Proliferation | NEGATIVELY CORRELATED WITH | Multiple Myeloma |
| Lenalidomide | POSITIVELY REGULATES | Natural Killer Cell Activation |
| Natural Killer Cell Activation | TREATS | Multiple Myeloma |
| Lenalidomide | POSITIVELY REGULATES | Apoptotic Process |
| Apoptotic Process | NEGATIVELY CORRELATED WITH | Multiple Myeloma |
| Lenalidomide | NEGATIVELY REGULATES | Cellular Response To Interleukin-12 |
| Cellular Response To Interleukin-12 | POSITIVELY CORRELATED WITH | Multiple Myeloma |
| Lenalidomide | DECREASES ACTIVITY OF | Tumor Necrosis Factor |
| Tumor Necrosis Factor | POSITIVELY CORRELATED WITH | Multiple Myeloma |
| Lenalidomide | NEGATIVELY REGULATES | Cellular Response To Interleukin-1 |
| Lenalidomide | NEGATIVELY REGULATES | Cellular Response To Interleukin-6 |
| Cellular Response To Interleukin-1 | POSITIVELY CORRELATED WITH | Multiple Myeloma |
| Cellular Response To Interleukin-6 | POSITIVELY CORRELATED WITH | Multiple Myeloma |
Reference: