Path ID: DB00479_MESH_D002761_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:D000583 | amikacin | Drug |
| UniProt:P0A7S3 | 30S ribosomal protein S12 | Protein |
| MESH:D012336 | RNA, Ribosomal, 16S | ChemicalSubstance |
| GO:0015935 | small ribosomal subunit | CellularComponent |
| GO:0006412 | translation | BiologicalProcess |
| taxonomy:2 | Bacteria | OrganismTaxon |
| MESH:D002761 | Cholangitis | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Amikacin | DECREASES ACTIVITY OF | 30S Ribosomal Protein S12 |
| Amikacin | NEGATIVELY REGULATES | Rna, Ribosomal, 16S |
| 30S Ribosomal Protein S12 | PART OF | Small Ribosomal Subunit |
| Rna, Ribosomal, 16S | LOCATED IN | Small Ribosomal Subunit |
| Small Ribosomal Subunit | PARTICIPATES IN | Translation |
| Translation | OCCURS IN | Bacteria |
| Bacteria | CAUSES | Cholangitis |
Reference:
- https://go.drugbank.com/drugs/DB00479#mechanism-of-action
- https://drugs.ncats.io/drug/84319SGC3C
- https://en.wikipedia.org/wiki/Amikacin#Mechanism_of_action
- https://www.uniprot.org/uniprot/P0A7S3#function
- https://en.wikipedia.org/wiki/Prokaryotic_small_ribosomal_subunit
- https://en.wikipedia.org/wiki/Ascending_cholangitis