Path ID: DB00467_MESH_D014552_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:D015365 | enoxacin | Drug |
| UniProt:P48374 | DNA topoisomerase 4 subunit A | Protein |
| UniProt:Q5EP76 | DNA topoisomerase | Protein |
| UniProt:P48371 | DNA gyrase subunit A | Protein |
| UniProt:P22118 | DNA gyrase subunit B | Protein |
| GO:0006265 | DNA topological change | BiologicalProcess |
| taxonomy:562 | Escherichia coli | OrganismTaxon |
| MESH:D014552 | Urinary tract infectious disease | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Enoxacin | DECREASES ACTIVITY OF | Dna Topoisomerase 4 Subunit A |
| Enoxacin | DECREASES ACTIVITY OF | Dna Topoisomerase |
| Enoxacin | DECREASES ACTIVITY OF | Dna Gyrase Subunit A |
| Enoxacin | DECREASES ACTIVITY OF | Dna Gyrase Subunit B |
| Dna Topoisomerase 4 Subunit A | POSITIVELY REGULATES | Dna Topological Change |
| Dna Topoisomerase | POSITIVELY REGULATES | Dna Topological Change |
| Dna Gyrase Subunit A | POSITIVELY REGULATES | Dna Topological Change |
| Dna Gyrase Subunit B | POSITIVELY REGULATES | Dna Topological Change |
| Dna Topological Change | IN TAXON | Escherichia Coli |
| Escherichia Coli | CAUSES | Urinary Tract Infectious Disease |
Comment: Note that UniProt:Q5EP76 is not a reviewed UniProt annotation, rather unreviewed (protein inferred from homology).
Reference: