Path ID: DB00463_MESH_D004827_2
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:C084822 | Metharbital | Drug |
| GO:0005245 | Voltage-gated calcium channel activity | BiologicalProcess |
| GO:0061535 | Glutamate secretion, neurotransmission | BiologicalProcess |
| MESH:D004827 | Epilepsy | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Metharbital | NEGATIVELY REGULATES | Voltage-Gated Calcium Channel Activity |
| Voltage-Gated Calcium Channel Activity | POSITIVELY REGULATES | Glutamate Secretion, Neurotransmission |
| Glutamate Secretion, Neurotransmission | POSITIVELY CORRELATED WITH | Epilepsy |
Comment: Withdrawn. This annotation is for higher concentrations of metharbital which can inhibit the calcium-dependent release of neurotransmitters such as glutamate.
Reference: