Path ID: DB00463_MESH_D004827_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:C084822 | Metharbital | Drug |
| UniProt:P14867 | Gamma-aminobutyric acid receptor subunit alpha-1 | Protein |
| UniProt:P47869 | Gamma-aminobutyric acid receptor subunit alpha-2 | Protein |
| UniProt:P34903 | Gamma-aminobutyric acid receptor subunit alpha-3 | Protein |
| UniProt:P48169 | Gamma-aminobutyric acid receptor subunit alpha-4 | Protein |
| UniProt:P31644 | Gamma-aminobutyric acid receptor subunit alpha-5 | Protein |
| UniProt:Q16445 | Gamma-aminobutyric acid receptor subunit alpha-6 | Protein |
| GO:0022851 | GABA-gated chloride ion channel activity | MolecularActivity |
| GO:0060081 | Membrane hyperpolarization | BiologicalProcess |
| GO:0019228 | Neuronal action potential | BiologicalProcess |
| GO:0050806 | Positive regulation of synaptic transmission | BiologicalProcess |
| InterPro:IPR001320 | Ionotropic glutamate receptor | GeneFamily |
| MESH:D018698 | Glutamic Acid | ChemicalSubstance |
| GO:0061535 | Glutamate secretion, neurotransmission | BiologicalProcess |
| MESH:D004827 | Epilepsy | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Metharbital | POSITIVELY REGULATES | Gamma-Aminobutyric Acid Receptor Subunit Alpha-1 |
| Metharbital | POSITIVELY REGULATES | Gamma-Aminobutyric Acid Receptor Subunit Alpha-2 |
| Metharbital | POSITIVELY REGULATES | Gamma-Aminobutyric Acid Receptor Subunit Alpha-3 |
| Metharbital | POSITIVELY REGULATES | Gamma-Aminobutyric Acid Receptor Subunit Alpha-4 |
| Metharbital | POSITIVELY REGULATES | Gamma-Aminobutyric Acid Receptor Subunit Alpha-5 |
| Metharbital | POSITIVELY REGULATES | Gamma-Aminobutyric Acid Receptor Subunit Alpha-6 |
| Gamma-Aminobutyric Acid Receptor Subunit Alpha-6 | POSITIVELY REGULATES | Gaba-Gated Chloride Ion Channel Activity |
| Gamma-Aminobutyric Acid Receptor Subunit Alpha-1 | POSITIVELY REGULATES | Gaba-Gated Chloride Ion Channel Activity |
| Gamma-Aminobutyric Acid Receptor Subunit Alpha-2 | POSITIVELY REGULATES | Gaba-Gated Chloride Ion Channel Activity |
| Gamma-Aminobutyric Acid Receptor Subunit Alpha-3 | POSITIVELY REGULATES | Gaba-Gated Chloride Ion Channel Activity |
| Gamma-Aminobutyric Acid Receptor Subunit Alpha-4 | POSITIVELY REGULATES | Gaba-Gated Chloride Ion Channel Activity |
| Gamma-Aminobutyric Acid Receptor Subunit Alpha-5 | POSITIVELY REGULATES | Gaba-Gated Chloride Ion Channel Activity |
| Gaba-Gated Chloride Ion Channel Activity | POSITIVELY CORRELATED WITH | Membrane Hyperpolarization |
| Membrane Hyperpolarization | NEGATIVELY REGULATES | Neuronal Action Potential |
| Neuronal Action Potential | CONTRIBUTES TO | Positive Regulation Of Synaptic Transmission |
| Positive Regulation Of Synaptic Transmission | POSITIVELY CORRELATED WITH | Epilepsy |
| Metharbital | DECREASES ACTIVITY OF | Ionotropic Glutamate Receptor |
| Ionotropic Glutamate Receptor | MOLECULARLY INTERACTS WITH | Glutamic Acid |
| Glutamic Acid | POSITIVELY CORRELATED WITH | Glutamate Secretion, Neurotransmission |
| Glutamate Secretion, Neurotransmission | POSITIVELY CORRELATED WITH | Epilepsy |
Comment: Withdrawn
Reference: