Path ID: DB00458_MESH_D003866_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:D007099 | Imipramine | Drug |
| UniProt:P23975 | Sodium-dependent noradrenaline transporter | Protein |
| UniProt:P31645 | Sodium-dependent serotonin transporter | Protein |
| GO:0051620 | Norepinephrine uptake | BiologicalProcess |
| GO:0051610 | Serotonin uptake | BiologicalProcess |
| GO:0061533 | Norepinephrine secretion, neurotransmission | BiologicalProcess |
| GO:0060096 | Serotonin secretion, neurotransmission | BiologicalProcess |
| MESH:D003866 | Depressive disorder | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Imipramine | DECREASES ACTIVITY OF | Sodium-Dependent Noradrenaline Transporter |
| Imipramine | DECREASES ACTIVITY OF | Sodium-Dependent Serotonin Transporter |
| Sodium-Dependent Noradrenaline Transporter | POSITIVELY REGULATES | Norepinephrine Uptake |
| Sodium-Dependent Serotonin Transporter | POSITIVELY REGULATES | Serotonin Uptake |
| Norepinephrine Uptake | NEGATIVELY REGULATES | Norepinephrine Secretion, Neurotransmission |
| Serotonin Uptake | NEGATIVELY REGULATES | Serotonin Secretion, Neurotransmission |
| Norepinephrine Secretion, Neurotransmission | NEGATIVELY CORRELATED WITH | Depressive Disorder |
| Serotonin Secretion, Neurotransmission | NEGATIVELY CORRELATED WITH | Depressive Disorder |
Reference: