Path ID: DB00455_MESH_D006255_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:D017336 | loratadine | Drug |
| UniProt:P35367 | Histamine H1 receptor | Protein |
| GO:0004969 | histamine receptor activity | MolecularActivity |
| GO:0002441 | histamine secretion involved in inflammatory response | BiologicalProcess |
| HP:0007879 | Allergic conjunctivitis | PhenotypicFeature |
| HP:0009926 | Epiphora | PhenotypicFeature |
| MESH:D006255 | Seasonal allergic rhinitis | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Loratadine | DECREASES ACTIVITY OF | Histamine H1 Receptor |
| Histamine H1 Receptor | POSITIVELY REGULATES | Histamine Receptor Activity |
| Histamine Receptor Activity | POSITIVELY CORRELATED WITH | Histamine Secretion Involved In Inflammatory Response |
| Histamine Secretion Involved In Inflammatory Response | POSITIVELY CORRELATED WITH | Epiphora |
| Histamine Secretion Involved In Inflammatory Response | POSITIVELY CORRELATED WITH | Allergic Conjunctivitis |
| Epiphora | MANIFESTATION OF | Seasonal Allergic Rhinitis |
| Allergic Conjunctivitis | MANIFESTATION OF | Seasonal Allergic Rhinitis |
Reference: