Path ID: DB00454_MESH_D010146_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:D008614 | pethidine | Drug |
| UniProt:P41145 | Kappa-type opioid receptor | Protein |
| UniProt:P35372 | Mu-type opioid receptor | Protein |
| reactome:R-HSA-418594 | G alpha (i) signalling events | Pathway |
| UniProt:P20366 | Protachykinin-1 | Protein |
| GO:0061534 | gamma-aminobutyric acid secretion, neurotransmission | BiologicalProcess |
| GO:0061527 | dopamine secretion, neurotransmission | BiologicalProcess |
| GO:0014055 | acetylcholine secretion, neurotransmission | BiologicalProcess |
| GO:0061533 | norepinephrine secretion, neurotransmission | BiologicalProcess |
| GO:0098818 | hyperpolarization of postsynaptic membrane | BiologicalProcess |
| MESH:D010146 | Pain | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Pethidine | INCREASES ACTIVITY OF | Kappa-Type Opioid Receptor |
| Pethidine | INCREASES ACTIVITY OF | Mu-Type Opioid Receptor |
| Kappa-Type Opioid Receptor | PARTICIPATES IN | G Alpha (I) Signalling Events |
| Mu-Type Opioid Receptor | PARTICIPATES IN | G Alpha (I) Signalling Events |
| G Alpha (I) Signalling Events | DECREASES ABUNDANCE OF | Protachykinin-1 |
| G Alpha (I) Signalling Events | NEGATIVELY CORRELATED WITH | Gamma-Aminobutyric Acid Secretion, Neurotransmission |
| G Alpha (I) Signalling Events | NEGATIVELY CORRELATED WITH | Dopamine Secretion, Neurotransmission |
| G Alpha (I) Signalling Events | NEGATIVELY CORRELATED WITH | Acetylcholine Secretion, Neurotransmission |
| G Alpha (I) Signalling Events | NEGATIVELY CORRELATED WITH | Norepinephrine Secretion, Neurotransmission |
| Protachykinin-1 | NEGATIVELY CORRELATED WITH | Hyperpolarization Of Postsynaptic Membrane |
| Gamma-Aminobutyric Acid Secretion, Neurotransmission | NEGATIVELY CORRELATED WITH | Hyperpolarization Of Postsynaptic Membrane |
| Dopamine Secretion, Neurotransmission | NEGATIVELY CORRELATED WITH | Hyperpolarization Of Postsynaptic Membrane |
| Acetylcholine Secretion, Neurotransmission | NEGATIVELY CORRELATED WITH | Hyperpolarization Of Postsynaptic Membrane |
| Norepinephrine Secretion, Neurotransmission | NEGATIVELY CORRELATED WITH | Hyperpolarization Of Postsynaptic Membrane |
| Hyperpolarization Of Postsynaptic Membrane | POSITIVELY CORRELATED WITH | Pain |
Reference: