Path ID: DB00451_MESH_D007037_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:D013974 | Levothyroxine | Drug |
| MESH:D014284 | Triiodothyronine | ChemicalSubstance |
| UniProt:P10827 | Thyroid hormone receptor alpha | Protein |
| UniProt:P10828 | Thyroid hormone receptor beta | Protein |
| GO:0002154 | Thyroid hormone mediated signaling pathway | BiologicalProcess |
| GO:0001659 | Temperature homeostasis | BiologicalProcess |
| GO:0010460 | Positive regulation of heart rate | BiologicalProcess |
| GO:0120054 | Intestinal motility | BiologicalProcess |
| HP:0012378 | Fatigue | PhenotypicFeature |
| MESH:D007037 | Hypothyroidism | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Levothyroxine | HAS METABOLITE | Triiodothyronine |
| Triiodothyronine | INCREASES ACTIVITY OF | Thyroid Hormone Receptor Alpha |
| Triiodothyronine | INCREASES ACTIVITY OF | Thyroid Hormone Receptor Beta |
| Thyroid Hormone Receptor Alpha | POSITIVELY REGULATES | Thyroid Hormone Mediated Signaling Pathway |
| Thyroid Hormone Receptor Beta | POSITIVELY REGULATES | Thyroid Hormone Mediated Signaling Pathway |
| Thyroid Hormone Mediated Signaling Pathway | POSITIVELY REGULATES | Temperature Homeostasis |
| Thyroid Hormone Mediated Signaling Pathway | POSITIVELY CORRELATED WITH | Positive Regulation Of Heart Rate |
| Thyroid Hormone Mediated Signaling Pathway | POSITIVELY REGULATES | Intestinal Motility |
| Thyroid Hormone Mediated Signaling Pathway | NEGATIVELY CORRELATED WITH | Fatigue |
| Temperature Homeostasis | NEGATIVELY CORRELATED WITH | Hypothyroidism |
| Positive Regulation Of Heart Rate | NEGATIVELY CORRELATED WITH | Hypothyroidism |
| Intestinal Motility | NEGATIVELY CORRELATED WITH | Hypothyroidism |
| Fatigue | POSITIVELY CORRELATED WITH | Hypothyroidism |
Reference: