Path ID: DB00451_MESH_D006949_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:D013974 | Levothyroxine | Drug |
| MESH:D014284 | Triiodothyronine | ChemicalSubstance |
| UniProt:P10827 | Thyroid hormone receptor alpha | Protein |
| UniProt:P10828 | Thyroid hormone receptor beta | Protein |
| GO:0002154 | Thyroid hormone mediated signaling pathway | BiologicalProcess |
| UniProt:P01130 | Low-density lipoprotein receptor | Protein |
| MESH:D008078 | Cholesterol, LDL | ChemicalSubstance |
| UniProt:Q6Q788 | Apolipoprotein A-V | Protein |
| MESH:D014280 | Triglycerides | ChemicalSubstance |
| MESH:D006949 | Hyperlipidemia | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Levothyroxine | HAS METABOLITE | Triiodothyronine |
| Triiodothyronine | INCREASES ACTIVITY OF | Thyroid Hormone Receptor Alpha |
| Triiodothyronine | INCREASES ACTIVITY OF | Thyroid Hormone Receptor Beta |
| Thyroid Hormone Receptor Alpha | POSITIVELY REGULATES | Thyroid Hormone Mediated Signaling Pathway |
| Thyroid Hormone Receptor Beta | POSITIVELY REGULATES | Thyroid Hormone Mediated Signaling Pathway |
| Thyroid Hormone Mediated Signaling Pathway | INCREASES ACTIVITY OF | Low-Density Lipoprotein Receptor |
| Low-Density Lipoprotein Receptor | DECREASES ABUNDANCE OF | Cholesterol, Ldl |
| Cholesterol, Ldl | POSITIVELY CORRELATED WITH | Hyperlipidemia |
| Thyroid Hormone Mediated Signaling Pathway | INCREASES ACTIVITY OF | Apolipoprotein A-V |
| Apolipoprotein A-V | DECREASES ABUNDANCE OF | Triglycerides |
| Triglycerides | POSITIVELY CORRELATED WITH | Hyperlipidemia |
Reference: