Path ID: DB00449_MESH_D005902_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:C015173 | dipivefrine | Drug |
| MESH:D004837 | epinephrine | ChemicalSubstance |
| InterPro:IPR002233 | Adrenoceptor family | GeneFamily |
| GO:0004935 | adrenergic receptor activity | MolecularActivity |
| GO:0042310 | vasoconstriction | BiologicalProcess |
| UBERON:0001796 | Aqueous Humor | GrossAnatomicalStructure |
| HP:0007906 | Ocular Hypertension | PhenotypicFeature |
| MESH:D005902 | Open-angle glaucoma | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Dipivefrine | HAS METABOLITE | Epinephrine |
| Epinephrine | INCREASES ACTIVITY OF | Adrenoceptor Family |
| Adrenoceptor Family | PARTICIPATES IN | Adrenergic Receptor Activity |
| Adrenergic Receptor Activity | POSITIVELY REGULATES | Vasoconstriction |
| Vasoconstriction | NEGATIVELY CORRELATED WITH | Aqueous Humor |
| Aqueous Humor | POSITIVELY CORRELATED WITH | Ocular Hypertension |
| Ocular Hypertension | POSITIVELY CORRELATED WITH | Open-Angle Glaucoma |
Comment: Dipivefrin is a prodrug with little or no pharmacologically activity until it is hydrolyzed into epinephrine inside the human eye.
Reference: