Path ID: DB00445_MESH_D001943_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:D015251 | epirubicin | Drug |
| UniProt:P11388 | DNA topoisomerase 2-alpha | Protein |
| GO:0032993 | protein-DNA complex | CellularComponent |
| MESH:D005609 | Free Radicals | ChemicalSubstance |
| GO:0090734 | site of DNA damage | CellularComponent |
| GO:0006260 | DNA replication | BiologicalProcess |
| HP:0031377 | Abnormal cell proliferation | PhenotypicFeature |
| GO:0006915 | apoptotic process | BiologicalProcess |
| GO:0140014 | mitotic nuclear division | BiologicalProcess |
| MESH:D001943 | Breast Neoplasm | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Epirubicin | NEGATIVELY REGULATES | Mitotic Nuclear Division |
| Mitotic Nuclear Division | POSITIVELY CORRELATED WITH | Abnormal Cell Proliferation |
| Abnormal Cell Proliferation | POSITIVELY CORRELATED WITH | Breast Neoplasm |
| Epirubicin | DECREASES ABUNDANCE OF | Protein-Dna Complex |
| Protein-Dna Complex | HAS PARTICIPANT | Dna Topoisomerase 2-Alpha |
| Dna Topoisomerase 2-Alpha | POSITIVELY CORRELATED WITH | Dna Replication |
| Epirubicin | INCREASES ABUNDANCE OF | Free Radicals |
| Free Radicals | POSITIVELY CORRELATED WITH | Site Of Dna Damage |
| Site Of Dna Damage | POSITIVELY CORRELATED WITH | Apoptotic Process |
| Apoptotic Process | NEGATIVELY CORRELATED WITH | Breast Neoplasm |
| Dna Replication | POSITIVELY CORRELATED WITH | Abnormal Cell Proliferation |
| Dna Replication | POSITIVELY CORRELATED WITH | Mitotic Nuclear Division |
| Mitotic Nuclear Division | POSITIVELY CORRELATED WITH | Abnormal Cell Proliferation |
| Abnormal Cell Proliferation | MANIFESTATION OF | Breast Neoplasm |
Comment: The disease is denoted Carcinoma of breast in the original file as per DrugCentral. The drug intercaltes with DNA and prevents DNA replication and downstream processes, some of them involving UniProt:P11388, which leads to cell/tumour death.
Reference: