Path ID: DB00443_MESH_D009140_1

db00443-mesh-d009140-1

Concepts

Identifier Name Type
MESH:D001623 betamethasone Drug
UniProt:P04150 Glucocorticoid receptor Protein
UniProt:P04083 Annexin A1 Protein
UniProt:P47712 Cytosolic phospholipase A2 Protein
UniProt:P23219 Prostaglandin G/H synthase 1 Protein
UniProt:P35354 Prostaglandin G/H synthase 2 Protein
GO:0019370 leukotriene biosynthetic process BiologicalProcess
GO:0001516 prostaglandin biosynthetic process BiologicalProcess
GO:0006954 inflammatory response BiologicalProcess
HP:0012531 Pain PhenotypicFeature
MESH:D009140 Musculoskeletal Diseases Disease

Relationships

NOTE: predicates are annotated in Biolink Model (v1.3.0)

Subject Predicate Object
Betamethasone INCREASES ACTIVITY OF Glucocorticoid Receptor
Glucocorticoid Receptor INCREASES ACTIVITY OF Annexin A1
Glucocorticoid Receptor DECREASES ACTIVITY OF Prostaglandin G/H Synthase 1
Glucocorticoid Receptor DECREASES ACTIVITY OF Prostaglandin G/H Synthase 2
Annexin A1 DECREASES ACTIVITY OF Cytosolic Phospholipase A2
Prostaglandin G/H Synthase 1 POSITIVELY REGULATES Prostaglandin Biosynthetic Process
Prostaglandin G/H Synthase 2 POSITIVELY REGULATES Prostaglandin Biosynthetic Process
Cytosolic Phospholipase A2 POSITIVELY REGULATES Leukotriene Biosynthetic Process
Cytosolic Phospholipase A2 POSITIVELY REGULATES Prostaglandin Biosynthetic Process
Leukotriene Biosynthetic Process POSITIVELY CORRELATED WITH Inflammatory Response
Prostaglandin Biosynthetic Process POSITIVELY CORRELATED WITH Inflammatory Response
Inflammatory Response HAS PHENOTYPE Pain
Pain CONTRIBUTES TO Musculoskeletal Diseases

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