Path ID: DB00443_MESH_C562390_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:C580789 | betamethasone acetate | Drug |
| UniProt:P04150 | Glucocorticoid receptor | Protein |
| UniProt:O15528 | 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial | Protein |
| GO:0006816 | calcium ion transport | BiologicalProcess |
| HP:0003072 | Hypercalcemia | PhenotypicFeature |
| MESH:D044162 | Parathyroid Hormone-Related Protein | ChemicalSubstance |
| MESH:C562390 | Humoral Hypercalcemia Of Malignancy | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Betamethasone Acetate | INCREASES ACTIVITY OF | Glucocorticoid Receptor |
| Glucocorticoid Receptor | NEGATIVELY REGULATES | 25-Hydroxyvitamin D-1 Alpha Hydroxylase, Mitochondrial |
| 25-Hydroxyvitamin D-1 Alpha Hydroxylase, Mitochondrial | PARTICIPATES IN | Calcium Ion Transport |
| Calcium Ion Transport | POSITIVELY CORRELATED WITH | Hypercalcemia |
| Hypercalcemia | CAUSED BY | Parathyroid Hormone-Related Protein |
| Parathyroid Hormone-Related Protein | CONTRIBUTES TO | Humoral Hypercalcemia Of Malignancy |
Comment: Betamethasone acetate is the 21-acetate ester of betamethasone and also a synthetic glucocorticoid corticosteroid.
Reference:
- https://go.drugbank.com/drugs/DB00443#mechanism-of-action
- https://drugs.ncats.io/drug/9842X06Q6M
- https://www.uniprot.org/uniprot/O15528#function
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4675637/
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5442343/
- https://en.wikipedia.org/wiki/Parathyroid_hormone-related_protein
- https://en.wikipedia.org/wiki/Parathyroid_hormone-related_protein#Humoral_hypercalcemia_of_malignancy