Path ID: DB00440_MESH_D004405_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:D014295 | trimethoprim | Drug |
| Pfam:PF00186 | Dihydrofolate reductase | GeneFamily |
| GO:0046654 | tetrahydrofolate biosynthetic process | BiologicalProcess |
| taxonomy:624 | Shigella sonnei | OrganismTaxon |
| MESH:D004405 | Shigellosis | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Trimethoprim | NEGATIVELY REGULATES | Dihydrofolate Reductase |
| Dihydrofolate Reductase | POSITIVELY REGULATES | Tetrahydrofolate Biosynthetic Process |
| Tetrahydrofolate Biosynthetic Process | IN TAXON | Shigella Sonnei |
| Shigella Sonnei | CAUSES | Shigellosis |
Reference: