Path ID: DB00435_MESH_D006976_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:D009569 | Nitric Oxide | Drug |
| InterPro:IPR001054 | Adenylyl cyclase class-3/4/guanylyl cyclase | GeneFamily |
| GO:0006182 | cGMP biosynthetic process | BiologicalProcess |
| MESH:D006152 | Cyclic GMP | ChemicalSubstance |
| GO:0042311 | vasodilation | BiologicalProcess |
| HP:0000822 | Hypertension | PhenotypicFeature |
| MESH:D006976 | Hypertension, Pulmonary | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Nitric Oxide | INCREASES ACTIVITY OF | Adenylyl Cyclase Class-3/4/Guanylyl Cyclase |
| Adenylyl Cyclase Class-3/4/Guanylyl Cyclase | POSITIVELY REGULATES | Cgmp Biosynthetic Process |
| Cgmp Biosynthetic Process | INCREASES ABUNDANCE OF | Cyclic Gmp |
| Cyclic Gmp | POSITIVELY REGULATES | Vasodilation |
| Vasodilation | NEGATIVELY CORRELATED WITH | Hypertension |
| Hypertension | MANIFESTATION OF | Hypertension, Pulmonary |
Reference: