Path ID: DB00432_MESH_D003110_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:D014271 | Trifluridine | Drug |
| UniProt:P04818 | Thymidylate synthase | Protein |
| GO:0006235 | dTTP biosynthetic process | BiologicalProcess |
| GO:0006231 | dTMP biosynthetic process | BiologicalProcess |
| GO:0006260 | DNA replication | BiologicalProcess |
| HP:0031377 | Abnormal cell proliferation | PhenotypicFeature |
| MESH:D004247 | DNA | ChemicalSubstance |
| MESH:D003110 | Malignant tumor of colon | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Trifluridine | DECREASES ACTIVITY OF | Thymidylate Synthase |
| Trifluridine | DISRUPTS | Dna |
| Dna | PARTICIPATES IN | Dna Replication |
| Thymidylate Synthase | POSITIVELY REGULATES | Dttp Biosynthetic Process |
| Thymidylate Synthase | POSITIVELY REGULATES | Dtmp Biosynthetic Process |
| Dtmp Biosynthetic Process | POSITIVELY CORRELATED WITH | Dna Replication |
| Dttp Biosynthetic Process | POSITIVELY CORRELATED WITH | Dna Replication |
| Dna Replication | PRECEDES | Abnormal Cell Proliferation |
| Abnormal Cell Proliferation | POSITIVELY CORRELATED WITH | Malignant Tumor Of Colon |
Reference: