Path ID: DB00422_MESH_D001289_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:D008774 | methylphenidate | Drug |
| UniProt:Q01959 | Sodium-dependent dopamine transporter | Protein |
| UniProt:P23975 | Sodium-dependent noradrenaline transporter | Protein |
| GO:0090494 | dopamine uptake | BiologicalProcess |
| GO:0051620 | norepinephrine uptake | BiologicalProcess |
| MESH:D001289 | Attention deficit hyperactivity disorder | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Methylphenidate | DECREASES ACTIVITY OF | Sodium-Dependent Dopamine Transporter |
| Methylphenidate | DECREASES ACTIVITY OF | Sodium-Dependent Noradrenaline Transporter |
| Sodium-Dependent Dopamine Transporter | POSITIVELY REGULATES | Dopamine Uptake |
| Sodium-Dependent Noradrenaline Transporter | POSITIVELY REGULATES | Norepinephrine Uptake |
| Norepinephrine Uptake | POSITIVELY CORRELATED WITH | Attention Deficit Hyperactivity Disorder |
| Dopamine Uptake | POSITIVELY CORRELATED WITH | Attention Deficit Hyperactivity Disorder |
Comment: This drug may be able to bind to UniProt:P08908 but its pharmacological activity (agonism vs. antagonism) is not known (https://go.drugbank.com/drugs/DB00422#BE0000291).
Reference: