Path ID: DB00421_MESH_D004487_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:D013148 | spironolactone | Drug |
| UniProt:P08235 | Mineralocorticoid receptor | Protein |
| MESH:D000450 | aldosterone | ChemicalSubstance |
| GO:0070294 | renal sodium ion absorption | BiologicalProcess |
| GO:0003092 | renal water retention | BiologicalProcess |
| MESH:D004487 | Edema | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Spironolactone | NEGATIVELY REGULATES | Mineralocorticoid Receptor |
| Mineralocorticoid Receptor | POSITIVELY CORRELATED WITH | Aldosterone |
| Aldosterone | CONTRIBUTES TO | Renal Sodium Ion Absorption |
| Renal Sodium Ion Absorption | POSITIVELY CORRELATED WITH | Renal Water Retention |
| Renal Water Retention | CONTRIBUTES TO | Edema |
Reference: