Path ID: DB00420_MESH_D009325_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:D011395 | promazine | Drug |
| UniProt:P14416 | D(2) dopamine receptor | Protein |
| UniProt:P28223 | 5-hydroxytryptamine receptor 2A | Protein |
| UniProt:P35367 | Histamine H1 receptor | Protein |
| GO:0014046 | dopamine secretion | BiologicalProcess |
| GO:0001820 | serotonin secretion | BiologicalProcess |
| GO:0001821 | histamine secretion | BiologicalProcess |
| MESH:D004298 | Dopamine | ChemicalSubstance |
| MESH:D012701 | Serotonin | ChemicalSubstance |
| MESH:D006632 | Histamine | ChemicalSubstance |
| MESH:D009325 | Nausea | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Promazine | DECREASES ACTIVITY OF | D(2) Dopamine Receptor |
| Promazine | DECREASES ACTIVITY OF | 5-Hydroxytryptamine Receptor 2A |
| Promazine | DECREASES ACTIVITY OF | Histamine H1 Receptor |
| D(2) Dopamine Receptor | POSITIVELY REGULATES | Dopamine Secretion |
| 5-Hydroxytryptamine Receptor 2A | POSITIVELY REGULATES | Serotonin Secretion |
| Histamine H1 Receptor | POSITIVELY REGULATES | Histamine Secretion |
| Dopamine Secretion | POSITIVELY CORRELATED WITH | Dopamine |
| Serotonin Secretion | POSITIVELY CORRELATED WITH | Serotonin |
| Histamine Secretion | POSITIVELY CORRELATED WITH | Histamine |
| Dopamine | POSITIVELY CORRELATED WITH | Nausea |
| Serotonin | POSITIVELY CORRELATED WITH | Nausea |
| Histamine | POSITIVELY CORRELATED WITH | Nausea |
Comment: Promazine is a phenothiazine drug that is uesd in short-term treatment of disturbed behavior and as an antiemetic. Promazine is currently not approved for human use in the United States.
Reference: