Path ID: DB00419_MESH_D005776_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:C059896 | miglustat | Drug |
| UniProt:Q16739 | Ceramide glucosyltransferase | Protein |
| GO:0006679 | glucosylceramide biosynthetic process | BiologicalProcess |
| CHEBI:36500 | glucosylceramide | ChemicalSubstance |
| MESH:D005776 | Glucosylceramide beta-glucosidase deficiency | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Miglustat | DECREASES ACTIVITY OF | Ceramide Glucosyltransferase |
| Ceramide Glucosyltransferase | POSITIVELY REGULATES | Glucosylceramide Biosynthetic Process |
| Glucosylceramide Biosynthetic Process | INCREASES ABUNDANCE OF | Glucosylceramide |
| Glucosylceramide | POSITIVELY CORRELATED WITH | Glucosylceramide Beta-Glucosidase Deficiency |
Comment: Miglustat is an example of a substrate reduction therapy and it inhibits the synthesis of glucosylceramide (also known as glucocerebroside).
Reference: