Path ID: DB00414_MESH_D003924_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:D000092 | Acetohexamide | Drug |
| UniProt:P48048 | ATP-sensitive inward rectifier potassium channel 1 | Protein |
| GO:0051899 | membrane depolarization | BiologicalProcess |
| GO:0005245 | voltage-gated calcium channel activity | MolecularActivity |
| GO:0070509 | calcium ion import | BiologicalProcess |
| GO:0030073 | insulin secretion | BiologicalProcess |
| HP:0001943 | Hypoglycemia | PhenotypicFeature |
| MESH:D003924 | Diabetes Mellitus, Type 2 | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Acetohexamide | DECREASES ACTIVITY OF | Atp-Sensitive Inward Rectifier Potassium Channel 1 |
| Atp-Sensitive Inward Rectifier Potassium Channel 1 | NEGATIVELY CORRELATED WITH | Membrane Depolarization |
| Membrane Depolarization | POSITIVELY REGULATES | Voltage-Gated Calcium Channel Activity |
| Voltage-Gated Calcium Channel Activity | POSITIVELY CORRELATED WITH | Calcium Ion Import |
| Calcium Ion Import | POSITIVELY REGULATES | Insulin Secretion |
| Insulin Secretion | POSITIVELY CORRELATED WITH | Hypoglycemia |
| Hypoglycemia | NEGATIVELY CORRELATED WITH | Diabetes Mellitus, Type 2 |
Comment: The drug, acetohexamide has been withdrawn from the US.
Reference: