Path ID: DB00408_MESH_D001714_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:D008152 | loxapine | Drug |
| UniProt:P14416 | Dopamine D2 receptor | Protein |
| UniProt:P28223 | 5-hydroxytryptamine receptor 2A | Protein |
| MESH:D004298 | dopamine | ChemicalSubstance |
| MESH:D012701 | serotonin | ChemicalSubstance |
| GO:0061527 | dopamine secretion, neurotransmission | BiologicalProcess |
| GO:0060096 | Serotonin secretion, neurotransmission | BiologicalProcess |
| MESH:D001714 | Bipolar disorder | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Loxapine | DECREASES ACTIVITY OF | Dopamine D2 Receptor |
| Loxapine | DECREASES ACTIVITY OF | 5-Hydroxytryptamine Receptor 2A |
| Dopamine D2 Receptor | POSITIVELY CORRELATED WITH | Dopamine |
| 5-Hydroxytryptamine Receptor 2A | POSITIVELY CORRELATED WITH | Serotonin |
| Dopamine | POSITIVELY CORRELATED WITH | Dopamine Secretion, Neurotransmission |
| Serotonin | POSITIVELY CORRELATED WITH | Serotonin Secretion, Neurotransmission |
| Serotonin Secretion, Neurotransmission | CORRELATED WITH | Bipolar Disorder |
| Dopamine Secretion, Neurotransmission | CORRELATED WITH | Bipolar Disorder |
Reference: