Path ID: DB00401_MESH_D006973_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:D015737 | Nisoldipine | Drug |
| InterPro:IPR005446 | Voltage-dependent calcium channel, L-type, alpha-1 subunit | GeneFamily |
| UniProt:P54289 | Voltage-dependent calcium channel subunit alpha-2/delta-1 | Protein |
| UniProt:Q08289 | Voltage-dependent L-type calcium channel subunit beta-2 | Protein |
| GO:0070509 | calcium ion import | BiologicalProcess |
| GO:0006939 | smooth muscle contraction | BiologicalProcess |
| GO:0042310 | vasoconstriction | BiologicalProcess |
| MESH:D006973 | Hypertension | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Nisoldipine | NEGATIVELY REGULATES | Voltage-Dependent Calcium Channel, L-Type, Alpha-1 Subunit |
| Nisoldipine | DECREASES ACTIVITY OF | Voltage-Dependent Calcium Channel Subunit Alpha-2/Delta-1 |
| Nisoldipine | DECREASES ACTIVITY OF | Voltage-Dependent L-Type Calcium Channel Subunit Beta-2 |
| Voltage-Dependent Calcium Channel, L-Type, Alpha-1 Subunit | POSITIVELY REGULATES | Calcium Ion Import |
| Voltage-Dependent Calcium Channel Subunit Alpha-2/Delta-1 | POSITIVELY REGULATES | Calcium Ion Import |
| Voltage-Dependent L-Type Calcium Channel Subunit Beta-2 | POSITIVELY REGULATES | Calcium Ion Import |
| Calcium Ion Import | POSITIVELY CORRELATED WITH | Smooth Muscle Contraction |
| Smooth Muscle Contraction | POSITIVELY CORRELATED WITH | Vasoconstriction |
| Vasoconstriction | POSITIVELY CORRELATED WITH | Hypertension |
Reference: