Path ID: DB00399_MESH_C562390_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:C088658 | zoledronic acid | Drug |
| UniProt:P14324 | Farnesyl pyrophosphate synthase | Protein |
| UniProt:O95749 | Geranylgeranyl pyrophosphate synthase | Protein |
| CHEBI:52255 | hydroxylapatite | ChemicalSubstance |
| CL:0000092 | osteoclast | Cell |
| GO:0045453 | bone resorption | BiologicalProcess |
| GO:0008299 | isoprenoid biosynthetic process | BiologicalProcess |
| GO:0006915 | apoptotic process | BiologicalProcess |
| GO:0001503 | ossification | BiologicalProcess |
| GO:1990523 | bone regeneration | BiologicalProcess |
| MESH:C562390 | Humoral hypercalcemia of malignancy | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Zoledronic Acid | DECREASES ACTIVITY OF | Farnesyl Pyrophosphate Synthase |
| Zoledronic Acid | DECREASES ACTIVITY OF | Geranylgeranyl Pyrophosphate Synthase |
| Farnesyl Pyrophosphate Synthase | POSITIVELY CORRELATED WITH | Isoprenoid Biosynthetic Process |
| Geranylgeranyl Pyrophosphate Synthase | POSITIVELY CORRELATED WITH | Isoprenoid Biosynthetic Process |
| Isoprenoid Biosynthetic Process | POSITIVELY CORRELATED WITH | Bone Resorption |
| Zoledronic Acid | POSITIVELY REGULATES | Apoptotic Process |
| Apoptotic Process | DECREASES ABUNDANCE OF | Osteoclast |
| Osteoclast | POSITIVELY CORRELATED WITH | Bone Resorption |
| Bone Resorption | POSITIVELY CORRELATED WITH | Humoral Hypercalcemia Of Malignancy |
| Zoledronic Acid | MOLECULARLY INTERACTS WITH | Hydroxylapatite |
| Hydroxylapatite | POSITIVELY CORRELATED WITH | Ossification |
| Hydroxylapatite | POSITIVELY CORRELATED WITH | Bone Regeneration |
| Bone Regeneration | NEGATIVELY CORRELATED WITH | Humoral Hypercalcemia Of Malignancy |
| Ossification | NEGATIVELY CORRELATED WITH | Humoral Hypercalcemia Of Malignancy |
Reference: