Path ID: DB00398_MESH_D002292_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:C471405 | Sorafenib | Drug |
| InterPro:IPR011009 | Protein kinase-like domain superfamily | GeneFamily |
| UniProt:P04049 | RAF proto-oncogene serine/threonine-protein kinase | Protein |
| UniProt:P09619 | Platelet-derived growth factor receptor beta | Protein |
| UniProt:P17948 | Vascular endothelial growth factor receptor 1 | Protein |
| UniProt:P15056 | Serine/threonine-protein kinase B-raf | Protein |
| UniProt:P35916 | Vascular endothelial growth factor receptor 3 | Protein |
| UniProt:P35968 | Vascular endothelial growth factor receptor 2 | Protein |
| UniProt:P36888 | Receptor-type tyrosine-protein kinase FLT3 | Protein |
| UniProt:P10721 | Mast/stem cell growth factor receptor Kit | Protein |
| UniProt:P11362 | Fibroblast growth factor receptor 1 | Protein |
| UniProt:P07949 | Proto-oncogene tyrosine-protein kinase receptor Ret | Protein |
| reactome:R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | Pathway |
| GO:0008284 | Positive regulation of cell population proliferation | BiologicalProcess |
| GO:0045766 | Positive regulation of angiogenesis | BiologicalProcess |
| MESH:D002292 | Renal cell carcinoma | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Sorafenib | DECREASES ACTIVITY OF | Protein Kinase-Like Domain Superfamily |
| Protein Kinase-Like Domain Superfamily | POSITIVELY CORRELATED WITH | Raf Proto-Oncogene Serine/Threonine-Protein Kinase |
| Protein Kinase-Like Domain Superfamily | POSITIVELY CORRELATED WITH | Platelet-Derived Growth Factor Receptor Beta |
| Protein Kinase-Like Domain Superfamily | POSITIVELY CORRELATED WITH | Vascular Endothelial Growth Factor Receptor 1 |
| Protein Kinase-Like Domain Superfamily | POSITIVELY CORRELATED WITH | Serine/Threonine-Protein Kinase B-Raf |
| Protein Kinase-Like Domain Superfamily | POSITIVELY CORRELATED WITH | Vascular Endothelial Growth Factor Receptor 3 |
| Protein Kinase-Like Domain Superfamily | POSITIVELY CORRELATED WITH | Vascular Endothelial Growth Factor Receptor 2 |
| Protein Kinase-Like Domain Superfamily | POSITIVELY CORRELATED WITH | Receptor-Type Tyrosine-Protein Kinase Flt3 |
| Protein Kinase-Like Domain Superfamily | POSITIVELY CORRELATED WITH | Mast/Stem Cell Growth Factor Receptor Kit |
| Protein Kinase-Like Domain Superfamily | POSITIVELY CORRELATED WITH | Proto-Oncogene Tyrosine-Protein Kinase Receptor Ret |
| Protein Kinase-Like Domain Superfamily | POSITIVELY CORRELATED WITH | Fibroblast Growth Factor Receptor 1 |
| Serine/Threonine-Protein Kinase B-Raf | PARTICIPATES IN | Signaling By Receptor Tyrosine Kinases |
| Vascular Endothelial Growth Factor Receptor 3 | PARTICIPATES IN | Signaling By Receptor Tyrosine Kinases |
| Vascular Endothelial Growth Factor Receptor 2 | PARTICIPATES IN | Signaling By Receptor Tyrosine Kinases |
| Receptor-Type Tyrosine-Protein Kinase Flt3 | PARTICIPATES IN | Signaling By Receptor Tyrosine Kinases |
| Mast/Stem Cell Growth Factor Receptor Kit | PARTICIPATES IN | Signaling By Receptor Tyrosine Kinases |
| Fibroblast Growth Factor Receptor 1 | PARTICIPATES IN | Signaling By Receptor Tyrosine Kinases |
| Raf Proto-Oncogene Serine/Threonine-Protein Kinase | PARTICIPATES IN | Signaling By Receptor Tyrosine Kinases |
| Proto-Oncogene Tyrosine-Protein Kinase Receptor Ret | PARTICIPATES IN | Signaling By Receptor Tyrosine Kinases |
| Platelet-Derived Growth Factor Receptor Beta | PARTICIPATES IN | Signaling By Receptor Tyrosine Kinases |
| Vascular Endothelial Growth Factor Receptor 1 | PARTICIPATES IN | Signaling By Receptor Tyrosine Kinases |
| Signaling By Receptor Tyrosine Kinases | CONTRIBUTES TO | Positive Regulation Of Cell Population Proliferation |
| Signaling By Receptor Tyrosine Kinases | CONTRIBUTES TO | Positive Regulation Of Angiogenesis |
| Positive Regulation Of Cell Population Proliferation | CAUSES | Renal Cell Carcinoma |
| Positive Regulation Of Angiogenesis | CAUSES | Renal Cell Carcinoma |
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