Path ID: DB00397_MESH_D003139_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:D010665 | Phenylpropanolamine | Drug |
| UniProt:P35348 | Alpha-1A adrenergic receptor | Protein |
| UniProt:P07550 | Beta-2 adrenergic receptor | Protein |
| HP:4000007 | Bronchoconstriction | PhenotypicFeature |
| GO:0042310 | Vasoconstriction | BiologicalProcess |
| GO:0070254 | Mucus secretion | BiologicalProcess |
| MESH:D003139 | Common cold | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Phenylpropanolamine | INCREASES ACTIVITY OF | Alpha-1A Adrenergic Receptor |
| Phenylpropanolamine | INCREASES ACTIVITY OF | Beta-2 Adrenergic Receptor |
| Beta-2 Adrenergic Receptor | NEGATIVELY CORRELATED WITH | Bronchoconstriction |
| Bronchoconstriction | POSITIVELY CORRELATED WITH | Common Cold |
| Alpha-1A Adrenergic Receptor | POSITIVELY REGULATES | Vasoconstriction |
| Vasoconstriction | NEGATIVELY CORRELATED WITH | Mucus Secretion |
| Mucus Secretion | POSITIVELY CORRELATED WITH | Common Cold |
Comment: Phenylpropanolamine is a sympathomimetic that was previously used in nasal decongestants and weight loss products, but has been withdrawn by the FDA due to safety risks and lack of efficacy.
Reference: