Path ID: DB00390_MESH_D001281_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:D004077 | digoxin | Drug |
| UniProt:P05023 | Sodium/potassium-transporting ATPase subunit alpha-1 | Protein |
| GO:0006814 | sodium ion transport | BiologicalProcess |
| GO:1902656 | calcium ion import into cytosol | BiologicalProcess |
| GO:0060047 | heart contraction | BiologicalProcess |
| MESH:D001281 | Atrial fibrillation | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Digoxin | NEGATIVELY REGULATES | Sodium/Potassium-Transporting Atpase Subunit Alpha-1 |
| Sodium/Potassium-Transporting Atpase Subunit Alpha-1 | POSITIVELY REGULATES | Sodium Ion Transport |
| Sodium Ion Transport | NEGATIVELY CORRELATED WITH | Calcium Ion Import Into Cytosol |
| Calcium Ion Import Into Cytosol | NEGATIVELY CORRELATED WITH | Heart Contraction |
| Heart Contraction | CORRELATED WITH | Atrial Fibrillation |
Comment: Increased cytosolic calcium lowers heart rate by lengthening the cardiac action potential and improves contractility by increasing the availability of calcium for sarcomeric excitation–contraction coupling.
Reference: