Path ID: DB00381_MESH_D006973_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:D017311 | Amlodipine | Drug |
| UniProt:Q13936 | Voltage-dependent L-type calcium channel subunit alpha-1C | Protein |
| UniProt:Q9P0X4 | Voltage-dependent T-type calcium channel subunit alpha-1I | Protein |
| GO:0006939 | smooth muscle contraction | BiologicalProcess |
| GO:0042310 | vasoconstriction | BiologicalProcess |
| MESH:D006973 | Hypertension | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Amlodipine | DECREASES ACTIVITY OF | Voltage-Dependent L-Type Calcium Channel Subunit Alpha-1C |
| Amlodipine | DECREASES ACTIVITY OF | Voltage-Dependent T-Type Calcium Channel Subunit Alpha-1I |
| Voltage-Dependent L-Type Calcium Channel Subunit Alpha-1C | POSITIVELY REGULATES | Smooth Muscle Contraction |
| Voltage-Dependent T-Type Calcium Channel Subunit Alpha-1I | POSITIVELY REGULATES | Smooth Muscle Contraction |
| Smooth Muscle Contraction | POSITIVELY CORRELATED WITH | Vasoconstriction |
| Vasoconstriction | CONTRIBUTES TO | Hypertension |
Reference: