Path ID: DB00381_MESH_D000788_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:D017311 | Amlodipine | Drug |
| UniProt:Q13936 | Voltage-dependent L-type calcium channel subunit alpha-1C | Protein |
| UniProt:Q9P0X4 | Voltage-dependent T-type calcium channel subunit alpha-1I | Protein |
| GO:0006939 | smooth muscle contraction | BiologicalProcess |
| HP:0025637 | Vasospasm | PhenotypicFeature |
| MESH:D000788 | Angina Pectoris, Variant | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Amlodipine | DECREASES ACTIVITY OF | Voltage-Dependent L-Type Calcium Channel Subunit Alpha-1C |
| Amlodipine | DECREASES ACTIVITY OF | Voltage-Dependent T-Type Calcium Channel Subunit Alpha-1I |
| Voltage-Dependent L-Type Calcium Channel Subunit Alpha-1C | POSITIVELY REGULATES | Smooth Muscle Contraction |
| Voltage-Dependent T-Type Calcium Channel Subunit Alpha-1I | POSITIVELY REGULATES | Smooth Muscle Contraction |
| Smooth Muscle Contraction | POSITIVELY CORRELATED WITH | Vasospasm |
| Vasospasm | CONTRIBUTES TO | Angina Pectoris, Variant |
Reference: