Path ID: DB00370_MESH_D003865_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:C035133 | Mirtazapine | Drug |
| UniProt:P28223 | 5-hydroxytryptamine receptor 2A | Protein |
| UniProt:P28335 | 5-hydroxytryptamine receptor 2C | Protein |
| UniProt:Q9UE69 | 5HT3 serotonin receptor | Protein |
| UniProt:P08913 | Alpha-2A adrenergic receptor | Protein |
| MESH:D012701 | Serotonin | ChemicalSubstance |
| GO:0032099 | Negative regulation of appetite | BiologicalProcess |
| HP:0000739 | Anxiety | PhenotypicFeature |
| HP:0002360 | Sleep disturbance | PhenotypicFeature |
| MESH:D003865 | Major depressive disorder | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Mirtazapine | DECREASES ACTIVITY OF | 5-Hydroxytryptamine Receptor 2A |
| Mirtazapine | DECREASES ACTIVITY OF | 5-Hydroxytryptamine Receptor 2C |
| Mirtazapine | DECREASES ACTIVITY OF | 5Ht3 Serotonin Receptor |
| Mirtazapine | DECREASES ACTIVITY OF | Alpha-2A Adrenergic Receptor |
| 5-Hydroxytryptamine Receptor 2A | POSITIVELY CORRELATED WITH | Serotonin |
| 5-Hydroxytryptamine Receptor 2C | POSITIVELY CORRELATED WITH | Serotonin |
| 5Ht3 Serotonin Receptor | POSITIVELY CORRELATED WITH | Serotonin |
| Alpha-2A Adrenergic Receptor | POSITIVELY CORRELATED WITH | Serotonin |
| Serotonin | POSITIVELY CORRELATED WITH | Negative Regulation Of Appetite |
| Serotonin | POSITIVELY CORRELATED WITH | Anxiety |
| Serotonin | POSITIVELY CORRELATED WITH | Sleep Disturbance |
| Negative Regulation Of Appetite | POSITIVELY CORRELATED WITH | Major Depressive Disorder |
| Anxiety | POSITIVELY CORRELATED WITH | Major Depressive Disorder |
| Sleep Disturbance | POSITIVELY CORRELATED WITH | Major Depressive Disorder |
Comment: The (S)-(+) enantiomer of mirtazapine is responsible for antagonism of the serotonin 5-HT2A and 5-HT2C receptors, while the (R)-(–) enantiomer is responsible for antagonism of the 5-HT3 receptor.
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