Path ID: DB00360_MESH_D010661_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:C003402 | sapropterin | Drug |
| UniProt:P00439 | Phenylalanine-4-hydroxylase | Protein |
| GO:0004505 | phenylalanine 4-monooxygenase activity | MolecularActivity |
| CHEBI:28044 | phenylalanine | ChemicalSubstance |
| MESH:D010661 | Classical phenylketonuria | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Sapropterin | INCREASES ACTIVITY OF | Phenylalanine-4-Hydroxylase |
| Phenylalanine-4-Hydroxylase | POSITIVELY REGULATES | Phenylalanine 4-Monooxygenase Activity |
| Phenylalanine 4-Monooxygenase Activity | DECREASES ABUNDANCE OF | Phenylalanine |
| Phenylalanine | POSITIVELY CORRELATED WITH | Classical Phenylketonuria |
Reference: